A surprising finding after adenosine administration

نویسندگان

  • C. Timmermans
  • H. Wellens
چکیده

To facilitate the explanation of Fig. 1, the QRS complexes are labelled. The first two show a normal QRS preceded by a normal PR interval. Thereafter the QRS configuration changes. Complexes 3 to 6 show gradual widening, a frontal axis shift to horizontal and loss of the initial q in leads I and V6, an rS pattern in lead III, and the development of a left bundle branch block-like QRS configuration. There is also a gradual lengthening of the PR interval. These adenosineinduced changes can be explained by progressive delay and block in AV nodal conduction and progressive activation of the ventricle over a right-sided atriofascicular (AF) fibre, also known as a Mahaim fibre. This structure inserts in the ventricle in or close to the right bundle branch, ultimately resulting in the typical QRS configuration of beats 5 and 6 [1]. Then 4 P waves are not conducted to the ventricle because of complete block both in the AV node and the AF fibre. As described several years ago, in contrast to rapidly conducting accessory pathways, the AF fibre is sensitive to adenosine resulting in delay and block [2]. It is explained by its AV nodal-like cellular composition. In our patient, after adenosine administration during sinus rhythm, complete AV nodal block preceded block in the AF fibre. A similar observation was reported by Belhassen et al. [3]. Of interest is also what happened after the episode of complete AV block. QRS 7 shows AV nodal conduction. QRS 8 is

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Venlafaxine Attenuates Heat Hyperalgesia Independent of Adenosine or Opioid System in a Rat Model of Peripheral Neuropathy

Primarily opioidergic and adenosine mechanisms are considered to be involved in the antinociceptive effects of antidepressants. This study was designed to determine the efficacy of acute venlafaxine administration in alleviating symptoms of neuropathic pain and the role of endogenous adenosine and opioid systems in this effect of venlafaxine. We have evaluated the effect of caffeine, a non-sele...

متن کامل

Venlafaxine Attenuates Heat Hyperalgesia Independent of Adenosine or Opioid System in a Rat Model of Peripheral Neuropathy

Primarily opioidergic and adenosine mechanisms are considered to be involved in the antinociceptive effects of antidepressants. This study was designed to determine the efficacy of acute venlafaxine administration in alleviating symptoms of neuropathic pain and the role of endogenous adenosine and opioid systems in this effect of venlafaxine. We have evaluated the effect of caffeine, a non-sele...

متن کامل

Sertraline alters level of adenosine deaminase activity, oxidative stress markers and cardiac biomarkers (homocysteine cardiac troponin I) in rats

The aim of this study is whether oxidative stress markers, homocysteine (Hcy), cardiac troponin I (cTnI) and the activity of adenosine deaminase (ADA) alter following administration of different doses of sertraline. Sixty male Wistar rats were assigned into four groups. Sertraline at doses of 20, 40 and 80 mg / kg / day) were administered to three groups through gastric gavage for 90 days. The ...

متن کامل

Analgesic Effect of a Single Dose of Adenosine for Neuropathic Pain Reduction in a Patient with Primitive Neuroechtodermal Tumor

Background: We report the analgesic efficacy of lumbar epidural adenosine injection in reducing the chronic neuropathic pain in a patient with primitive neuroectodermal tumor. Report of the Case: In this case report a 13-year-old male with primary neuroectodermal tumor (PNET) was administered in epidural space with adenosine to reduce his pain. The patient received 10ml of 0.25% ropivacaine ...

متن کامل

The effect of adenosine and caffeine on paragigantocellularis (PGi) nucleus neurons in morphine-dependent rats

In this study the effect of adenosine and caffeine on spontaneous activity of paragigantocellularis (PGi) neurons was investigated. The spontaneous activity of PGi neurons was significantly decreased by microinjection of adenosine (10 nM, 0.5 µl) into PGi nucleus of both control and morphine-dependent rats. The decrease in firing rate of PGi neurons of morphine-dependent rats was greater than t...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 25  شماره 

صفحات  -

تاریخ انتشار 2017